作者: 形狀 時(shí)間: 2025-3-21 23:49
Modulating Cholinergic Neurotransmission Through Transgenic Overexpression of Human Cholinesterasescholinergic synapses of . tadpoles and mice. Cholinesterase over-expression should create a local deficit of acetylcholine at the “engineered” synapses and initiate feedback responses from which one may learn about the role of cholinergic neurotransmission in regulating synaptic structure and function.作者: 浪費(fèi)物質(zhì) 時(shí)間: 2025-3-22 03:15 作者: 善辯 時(shí)間: 2025-3-22 07:53 作者: 送秋波 時(shí)間: 2025-3-22 10:24
Die Bankkalkulation in der Praxischolinergic synapses of . tadpoles and mice. Cholinesterase over-expression should create a local deficit of acetylcholine at the “engineered” synapses and initiate feedback responses from which one may learn about the role of cholinergic neurotransmission in regulating synaptic structure and function.作者: nettle 時(shí)間: 2025-3-22 15:50
https://doi.org/10.1007/978-3-322-98662-7 of ACh (Quinn, 1987). A second, ‘peripheral’ anionic site is so named since it is distant from the active site (Taylor and Lappi, 1975). Bisquaternary AChE inhibitors derive their enhanced potency, relative to homologous monoquatemary ligands (Main, 1976), from their ability to span these two `anionic’ sites, which are .. 14 à apart.作者: 鄙視讀作 時(shí)間: 2025-3-22 20:59
Conference proceedings 1994 metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in unde作者: 不能平靜 時(shí)間: 2025-3-22 21:40
ay involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critic作者: effrontery 時(shí)間: 2025-3-23 05:06 作者: 急急忙忙 時(shí)間: 2025-3-23 06:04 作者: Introduction 時(shí)間: 2025-3-23 11:25 作者: ambivalence 時(shí)間: 2025-3-23 15:53
Development of Drugs for Alzheimer Therapy: A Decade of Progresstified approximately 100 compounds proposed for use in Alzheimer disease (AD) therapy. We have found reference to over 300 studies conducted in humans. These studies have involved a total of about 3,000 patients.作者: podiatrist 時(shí)間: 2025-3-23 21:36 作者: 輕而薄 時(shí)間: 2025-3-23 22:27 作者: calumniate 時(shí)間: 2025-3-24 02:55
,Kontoführung, Kontokorrent-Abschlu?,, outline and discuss some of the criticisms of the cascade hypothesis (Problems) and point to some of the many gaping holes in our knowledge of the disease with respect to this hypothesis (Deficiencies).作者: Organization 時(shí)間: 2025-3-24 07:06 作者: Entreaty 時(shí)間: 2025-3-24 12:49
,Die Devisen- und Au?enhandelsgesch?fte,th an allele frequency of 0.40 ± 0.026. The apoE gene dose is a major risk factor for late onset AD, and in these families homozygosity for APOE4 is virtually sufficient to cause AD by age 80 (Corder et al.,1993). The apoE 2 allele decreases risk (Corder et al., 1994).作者: 拒絕 時(shí)間: 2025-3-24 15:04
Amyloid Deposition as the Central Event in the Etiology and Pathogenesis of Alzheimer’s Disease, outline and discuss some of the criticisms of the cascade hypothesis (Problems) and point to some of the many gaping holes in our knowledge of the disease with respect to this hypothesis (Deficiencies).作者: 修飾 時(shí)間: 2025-3-24 19:19 作者: expunge 時(shí)間: 2025-3-25 02:05 作者: 獎(jiǎng)牌 時(shí)間: 2025-3-25 03:37 作者: 影響 時(shí)間: 2025-3-25 08:23 作者: Fibrillation 時(shí)間: 2025-3-25 13:31 作者: 發(fā)現(xiàn) 時(shí)間: 2025-3-25 17:05 作者: Nonconformist 時(shí)間: 2025-3-25 21:27
Development of Drugs for Alzheimer Therapy: A Decade of Progressre, some comparisons seem both useful and appropriate. In the seven years (1988–1994) since our first volume (Giacobini and Becker, 1988) we have identified approximately 100 compounds proposed for use in Alzheimer disease (AD) therapy. We have found reference to over 300 studies conducted in humans作者: octogenarian 時(shí)間: 2025-3-26 03:20 作者: 攝取 時(shí)間: 2025-3-26 05:16 作者: 忘恩負(fù)義的人 時(shí)間: 2025-3-26 09:51 作者: 尾巴 時(shí)間: 2025-3-26 14:41
Role of Abnormal Phosphorylation of Tau in Neurofibrillary Degeneration: Implications for Alzheimer hologically, Alzheimer disease (AD) is characterized by the presence of two brain lesions, paired helical filaments (PHF) in the neurons and ?-amyloid in the extracellular space. At present, the exact relationship between PHF and ?-amyloid in the pathogenesis of AD is not understood. However, there 作者: 大炮 時(shí)間: 2025-3-26 20:24
Olfactory Bulb Involvement in AD: An Early Changenaming of the odorant (Serby et al., 1985; Peabody and Tinklenberg, 1985; Warner et al., 1986; Knupfer and Speigel, 1986; Doty et al., 1987). In contrast, detecting the presence of an odorant (i.e. detection) or discriminating that two odorants are different (discrimination) appear to be relatively 作者: 旁觀(guān)者 時(shí)間: 2025-3-26 23:48
Alzheimer Disease -- A Spirochetosis?e of neuroborreliosis caused by . (Burgdorfer et al., 1982; Pachner et al., 1989), and general paresis, tertiary stage of neurosyphilis caused by .. Two cases of concurrent neocortical borreliosis and Alzheimer disease (AD) have been reported (MacDonald and Miranda, 1987; MacDonald, 1988): immunosta作者: AMBI 時(shí)間: 2025-3-27 03:17 作者: deriver 時(shí)間: 2025-3-27 07:31 作者: ABOUT 時(shí)間: 2025-3-27 11:17 作者: 可轉(zhuǎn)變 時(shí)間: 2025-3-27 16:37
Apolipoprotein E and Alzheimer’s Disease: Therapeutic Implicationsd with late-onset familial (Strittmatter et al., 1993a) and sporadic (Saunders et al., 1993) AD. Three major protein isoforms of apoE (apoE2, E3 and E4) are the products of three alleles ?2, ?3, ?4 at a single gene locus on the proximal long arm of chromosome 19q13.2 (Mahley, 1988), within the regio作者: 600 時(shí)間: 2025-3-27 17:46
Apolipoprotein E4 and Cholinergic Dysfunction in Alzheimer’s Diseaseily by the liver, but also at other sites including brain, macrophages and adrenals (Elshourbagy et al., 1985). Furthermore, apoE is unique among apolipoproteins in that it has a special relevance to the central and peripheral nervous systems. It is a key determinant in the cellular recognition and 作者: uveitis 時(shí)間: 2025-3-27 22:11 作者: 朝圣者 時(shí)間: 2025-3-28 05:27
Modulating Cholinergic Neurotransmission Through Transgenic Overexpression of Human Cholinesterasestem (Harding, 1992), suggesting that experimental modulation of cholinergic neurotransmission can serve to study the relationship between cholinergic deficits and neuropathology. To this end, we established transgenic models for overexpressing human cholinesterases (ChEs) (Soreq and Zakut, 1993) in 作者: MINT 時(shí)間: 2025-3-28 07:00
Structure-Function Relationships in The Binding of Reversible Inhibitors in the Active-Site Gorge ofase agents are used in treatment of various disorders (Taylor, 1990), and have been proposed as therapeutic agents for managing Alzheimer’s disease (AD) (Becker and Giacobini, 1991). The AChE active site contains a catalytic subsite and a so-called `anionic’ subsite, which binds the quaternary group作者: 坦白 時(shí)間: 2025-3-28 14:23 作者: Expediency 時(shí)間: 2025-3-28 16:40
In Vitro Production of Amyloid β-Protein: A Route to the Mechanism and Treatment of Alzheimer’s Disethat the processing of ?APP into A? can actually cause Alzheimer’s disease has come from the identification by several laboratories of missense mutations in the ?APP gene within and flanking the A? region in affected members of certain families having Alzheimer’s disease or hereditary cerebral hemor作者: 刻苦讀書(shū) 時(shí)間: 2025-3-28 19:22 作者: 招待 時(shí)間: 2025-3-29 00:26 作者: Nonconformist 時(shí)間: 2025-3-29 04:41
Ezio Giacobini (Chairman of Pharmacology),Robert E作者: 深淵 時(shí)間: 2025-3-29 08:06
Conference proceedings 1994f apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-bin作者: nostrum 時(shí)間: 2025-3-29 12:37
ications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-bin978-1-4615-8151-2978-1-4615-8149-9作者: 巧辦法 時(shí)間: 2025-3-29 16:33
https://doi.org/10.1007/978-1-4615-8149-9Alzheimer‘s disease; Alzheimer′s disease; cell; diagnosis; gene; management; metabolism; neurons; pathology; 作者: 雀斑 時(shí)間: 2025-3-29 23:21 作者: 靦腆 時(shí)間: 2025-3-30 00:03 作者: flamboyant 時(shí)間: 2025-3-30 04:55 作者: 碎石 時(shí)間: 2025-3-30 10:27 作者: 詢(xún)問(wèn) 時(shí)間: 2025-3-30 13:50
,Kontoführung, Kontokorrent-Abschlu?,Hardy and Higgins, 1992) has become the dominant hypothesis for the etiology and pathogenesis of Alzheimer’s disease (AD). In the last two years, much work based on the cascade hypothesis has been published which offers more support for it as a framework for the development of an understanding of th作者: 紅潤(rùn) 時(shí)間: 2025-3-30 19:04 作者: Defiance 時(shí)間: 2025-3-31 00:43 作者: Laconic 時(shí)間: 2025-3-31 01:03
Wertpapier-Handel, Wertpapier-Emission,e of neuroborreliosis caused by . (Burgdorfer et al., 1982; Pachner et al., 1989), and general paresis, tertiary stage of neurosyphilis caused by .. Two cases of concurrent neocortical borreliosis and Alzheimer disease (AD) have been reported (MacDonald and Miranda, 1987; MacDonald, 1988): immunosta
